陈华-pg电子游戏试玩平台网站
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陈华

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电子邮箱:chenhuagnu@gxnu.edu.cn;chenhua_jsu@163.com

实验室地址:国重室1号楼608

基本介绍

陈华,博士,硕士生导师,广西杰出青年基金获得者。2017年6月毕业于湖南大学,获化学专业理学博士学位。同年加入广西师范大学化学与药学学院从事教学与科研工作,2020年12月晋升为副教授。主要从事染料化学生物学,分子探针与生物成像研究。相关研究成果在angewandte chemie, accounts of chemical research, advanced functional materials, chemical science等重要sci期刊发表论文30余篇,其中esi高被引论文3篇和热点论文1篇。研究成果获得了国内外同行的广泛关注,sci他引1500余次,单篇最高引用次数222次,单篇引用次数大于100的论文3篇。授权国家发明专利5项。先后主持国家自然科学基金2项和省部级项目3项。受邀担任frontiers in bioengineering and biotechnology专刊(opticalimaging technology for oxidative stress-mediated disease diagnosis)客座编辑。

每年招收多名硕士研究生和本科生,热忱欢迎有志从事科研工作的学生加入!

招生方向:有机化学/化学生物学/生物与医药

研究方向

1.染料化学生物学

2.分子探针与生物成像

讲授课程

有机化学实验,波谱分析,大学化学,综合化学实验,化学信息学

代表性论文

1. shuping zhang, hua chen*, liping wang, xue qin, bang-ping jiang, shi-chen ji, xing-can shen*and hong liang, a general approach to design dual ratiometric fluorescentand photoacoustic probe for quantitatively visualizing tumorhypoxia levels in vivo, angewandte chemie international edition, 2022,61, e202107076.

2. fangyuan cai,  bo hou,  shuping zhang,  hua chen*,  shi-chen ji,  xing-can shen*  and  hong liang, chromenoquinoline-based two-photon fluorescent probe for highly specific and fast visualizing sulfur dioxide derivatives in living cells and zebrafish, j. mater. chem. b, 2019, 10.1039/c9tb00179d

3. hua chen, wenqian liang, yang zhu, zhengxi guo, jing jian, bang-ping jiang, hong liang and xing-can shen*,supercharged fluorescent protein functionalized water-soluble poly(n-phenylglycine) nanoparticles for highly effective imaging-guided photothermal therapy, chem. commun., 2018, 54, 10292--10295

4. hua chen, baoli dong, yonghe tang, weiying lin*, a unique integration strategy for the rational design of optically tunable near-infrared fluorophores, accounts of chemical research,2017, 50, 1410-1422 

5. hua chen, huiming shang, yong liu, rui guo, and weiying lin*, development of a unique class of spiro-type two-photon fluorophores and their applications for sensing and bioimaging, advanced functional material,2016, 44, 8128-8136

6. hua chen,yonghe tang, mingguang ren, weiying lin*,single near-infrared fluorescent probe with high and low sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals,chemical science,2016, 7, 1896-1903. top 50 articles of 2016: analytical, biological and medicinal chemistry

7.hua chen, yonghe tang, weiying lin*, recent progress in the fluorescent probes for specific imaging of small molecular weight thiols in living cells,trends in analytical chemistry,2016, 76,166-181.

8.hua chen, baoli dong, yonghe tang, weiying lin*. construction of a near-infrared fluorescent turn-on probe for selenol and its bioimaging application in living animals.  chemistry - a european journal,2015, 21, 11696-11700.

9.hua chen, weiying lin*, wenqing jiang, baoli dong, haijun cui, and yonghe tang. locked-flavylium fluorescent dyes with tunable emission wavelengths based on intramolecular charge transfer for multi-color ratiometric fluorescence imaging.chemical communications.2015, 51, 6968 -6971.

10.hua chen, weiying lin*, haijun cui, wenqing jiang. development of unique xanthene-cyanine fused near-infrared fluorescent fluorophores with superior chemical stability for biological fluorescence imaging.chemistry - a european journal.2015,21, 733 -745. 


科研项目

(1)国家自然科学基金青年基金项目。项目批准号:21807016,项目名称:基于多通道比率型单荧光探针的过氧化亚硝酰和一氧化氮同步检测及成像。

(2)国家自然科学基金地区基金项目。项目批准号:22167004,项目名称:双色同步靶向线粒体和溶酶体的帕金森荧光探针研制及其生物成像研究。

(3)广西自然科学基金青年基金项目。项目编号:2018gxnsfba138040,项目名称:新型红光发射双光子荧光染料的构建及其识别多硫化氢的生物成像研究。

(4)广西科技基地和人才专项。项目编号:桂科ad19110015,项目名称:比率型分子探针用于重要活性氮物种的同时探测及成像研究。


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